Oncology Connection

Recent Articles

Unraveling VEXAS Syndrome: From Pathophysiology to Treatment Strategies and Future Horizons

Kristin Horwood ACNP-BC, AOCNP, MSN VEXAS Syndrome Overview VEXAS syndrome is a unique adult-onset disease with several varying clinical signs and symptoms. It is important for hematology/oncology advanced practice providers (APPs) to be aware of VEXAS syndrome as it is associated with several hematological disorders. V (vacuoles), E (E1 enzyme), X (X-linked), A (autoinflammatory), S (somatic mutation in ubiquitin-like modifier-activating enzyme 1 [UBA1] gene)1 syndrome was only recently described in 2020 as a new category of hemato-inflammatory diseases. This occurs from myeloid-driven inflammation arising from somatic mutations of the stem cell; in this case, mutations of the UBA1 gene.2 The syndrome is characterized by severe autoinflammation, which commonly presents with vasculitis, skin rash, polychondritis, arthritis, pulmonary inflammation, and constitutional symptoms. In a case series of 9 men with VEXAS syndrome, 88% had refractory constitutional symptoms that began 4 years prior to diagnosis.3 The diagnosis of VEXAS syndrome includes evidence of

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APP Career

From Chance to Choice: My Journey in Oncology

Jenny Veliz-Urzua, DNP, MBA, FNP-BC, RNFA When I started my career, I was set on primary care. I was motivated by the benefits of disease prevention and early intervention in healthcare delivery. I never considered oncology. Truthfully, the oncology specialty chose me. There was a job opportunity at the start

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Oncology Connection

Diagnosis & Treatment

Insulinoma: Diagnostic Challenges and Strategies

Sijimol Mathew, DNP, APRN, ACNP-BC Insulinomas originate from the uncontrolled growth of pancreatic beta cells. Chronic and recurrent hypoglycemia lowers the patient’s threshold to hypoglycemic insults; additionally, early morning hypoglycemia makes insulinoma

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Practice Improvement

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Solid Tumor

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Hematology

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Editorial Board

Beth Sandy, MSN, CRNP — Editor-in-Chief

Haleigh Mistry, MS, PA-C

Laura Alwan, PharmD, BCOP

Kelly Goodwin, NP

Ryan Beechinor, PharmD, BCOP

Jenny Veliz-Urzua, DNP, MSN, FNP-BC

Carol Peyton Bryant, DNP, RN, ACNP, CCRN

Victoria Nachar, PharmD, BCOP